Inclusion Criteria
Participant is willing and able to give informed consent for participation in the study;
Participant is willing to comply with all trial procedures;
Onset of symptoms of possible COVID-19 in the community (continuous cough and/or high temperature) within 7 days of inclusion;
Patients aged ≥50-64 years with any of the following listed comorbidities:
Known weakened immune system due to a serious illness or medication (e.g. chemotherapy);
Known heart disease and/ or hypertension;
Known asthma or lung disease;
Known diabetes not treated with insulin;
Known mild hepatic impairment;
Known stroke or neurological problem;
OR
Patients aged ≥65 with or without comorbidity
Exclusion Criteria
Pregnancy;
Breastfeeding;
Known severe hepatic impairment;
Known severe renal impairment;
Known porphyria;
Type 1 diabetes or insulin dependent Type 2 Diabetes mellitus ;
Known G6PD deficiency;
Known myasthenia gravis;
Known severe psoriasis;
Known severe neurological disorders (especially those with a history of epilepsy—may lower seizure threshold);
Previous adverse reaction to, or currently taking, hydroxychloroquine;
Patients taking the following drugs: penicillamine, amiodarone, ciclosporin, chloroquine
Known retinal disease;
Judgement of the recruiting clinician deems ineligible.
PARTICIPANTS INFORMATION LEAFLET
Please contact Nicola, the Practice Manager, if you believe you are eligible for this study